NextGen Bioscience, Inc. is a drug development biotechnology company focused on the identification, evaluation and acquisition of drug candidates for treatment and prevention of cancers and infectious diseases in human beings. “NextGen” leverages cutting-edge research collaborations to achieve breakthroughs in anti-cancer treatments, and then licenses these patented drug product candidates to Big Pharmaceutical companies.
NextGen’s business model is to acquire promising new patented technologies in the fields of cancer and infectious disease, to add significant value to these by advancing them through toxicological assessment or Phase I clinical trials and then outlicensing the technology to a larger partner who has the necessary infrastructure to take the products to market. All acquisition candidates are underpinned by patent applications or granted patents which confer protection in the major jurisdictions worldwide. Revenues generated from licensing activities will then be reinvested in research and development by NextGen to benefit patients, partners and the Company’s investors.
NextGen’s target market, cancer treatments, is the largest disease market, exploding at a 20% growth rate each year and says NextGen CEO, Konstantinos Kardiasmenos, “reaching a phenomenal global market volume of approximately $30 Billion.” Based upon deals achieved by other successful drug targets in the industry, in the event that NextGen’s proprietary product candidates successfully target significant unmet needs, the Company can expect up to $100 million in milestone payments per licensed product during clinical trials, and up to $400 million per annum in the years (up to 20 years) following commercialization. NextGen’s licensing fees could grow to $700 million per annum per product with market growth. This represents a significant catalyst for company growth which will in turn greatly benefit stakeholders.
NextGen is rapidly building its portfolio of proprietary biotechnology. The Company’s patented drug and product portfolio includes a prostate cancer target and a breast cancer target as well as a promising acquisition pipeline. These first two anti-tumor drug candidates, Prostaganin (prostate cancer) and Tetanolic (breast cancer), both have incredible market potential. With the potential to treat cancer in a way that is effective and safe for the patient, they may ultimately eliminate the need for surgery and chemotherapy and possess no side effects. An exciting acquisition pipeline, including in oncology therapeutics, cancer vaccines and anti-bacterial drugs, ensures that the Company is constantly positioned as a leader in the forefront of developments in treating cancer and infectious disease. All of NextGen’s product candidates target disease indications which represent a significant unmet need, as well as having blockbuster potential market values.
Based in London, NextGen is able to keep operating costs to a minimum by outsourcing all product development work to established specialist service providers and Universities to add significant value, but at low cost. NextGen’s World Class Management team and Scientific Advisory Board will guide and direct development of the products to add maximum value.
Additionally, NextGen has identified a number of promising potential acquisitions of R&D projects, which can be acquired immediately at costs significantly below past investments made in them. These, and other future acquisitions, will ensure that NextGen’s pipeline of products are maintained at the forefront of scientific and medical developments, again, bringing maximum benefit to stakeholders.
The main target indication area is cancer treatment and in particular:
1. Prostate cancer
2. Breast cancer
3. Colorectal cancer
Key parameters differentiating NextGen from other biotechnology companies:
* Corporate focus
* World-class Management Team and Scientific Advisory Board
* Potential value
* Pipeline of acquisition candidates
* Blockbuster Potential Strategy
* Leverage of resources
* Organizational Flexibility and low fixed overheads
* Opportunistic approach
NextGen’s Corporate focus is devoted to identification, evaluation and acquisition of drug targets and subsequent value addition to maximize benefits to stakeholders.
The Company’s World-class Management Team and Scientific Advisory Board direct product development, each with specialist experience in this field.
Potential value is built in the portfolio of pending patent applications for treatment of difficult to treat cancers (NextGen’s proprietary intellectual property).
Pipeline of acquisition candidates being evaluated is derived from global collaborations with other biotechnology companies and Universities.
Strategy of acquiring candidates which target indications with significant unmet needs and blockbuster market potential.
Highly flexible organization and low fixed overheads due to outsourcing strategy.
Leverage of resources through collaboration with well established service providers and academic laboratories.
Opportunistic approach characterized by swift decision making and ability to redirect research and business efforts quickly and at low cost, to maximize partnering activities.
Work on Infectious diseases
Infectious diseases comprise an emerging indication area for NextGen, particularly hospital acquired infections such as MRSA. MRSA infections are becoming more prevalent in healthcare settings: in 1974, MRSA infections accounted for two percent of the total number of infections; in 1995 it was 22 percent; and in 2004 it was 63 percent (US Centers for Disease Control, 2007). The bacteria responsible are increasingly resistant to existing antibiotics. One of NextGen’s potential acquisition candidates will target hospital acquired infections such as MRSA.
The Company is evaluating the potential of a protein drug which has shown potency in preventing bacterial infection. This product has a novel mechanism of action and could potentially revolutionize the prevention of hospital acquired infections, such as MRSA or C.difficile. Other new product candidates being evaluated for potential acquisition include a number of biological products which enable the destruction of a broad range of solid tumors, including colorectal and ovarian cancers.
A Leading Biotech
NextGen delivers a faster track for transfer of exceptional ideas and research into well-founded pharmaceutical development projects by bridging the gap between academic research groups and smaller biotech companies and the clinic. The fast track route is cost efficient and provides a longer exclusivity period in the market, thereby maximizing earnings potential and minimizing investor risk. Through a flexible and scalable organization due to out-sourcing NextGen is poised to make superior treatments available faster for patient and society and become a major leader in biotechnology.
Accomplished Management and Scientific Advisory Board
Typifying its world class member scientists, in January NextGen announced that Dr. Rolf Witte had joined its Scientific Advisory Board of esteemed scientists and entrepreneurial leaders. Dr. Rolf Witte is Founder, Partner and CEO of fundamenta CAPITAL AG based in Leverkusen Germany. fundamenta is a hands-on investment fund focused in the Biotech, Pharma, Medical Device and new technology sectors. Rolf is also Chief Financial Officer of CMI GmbH, a contract medical device company based in Dresden, Germany. Prior to founding fundamenta, Dr. Witte was CEO of Pegasus Beteiligungen AG, a publicly traded investment fund. Other past positions include numerous CFO positions of European textile companies, and work as a lawyer specializing in audit and tax advice. Dr. Witte’s academic background includes degrees in Economics and Law, Dipl. Kfm. and Ass. iur., as well as a Ph.D. in tax law from the University of Goettingen. He also was awarded a research fellowship by the DFG (Deutsche Forschungs Gemeinschaft) for researching VAT harmonization at the European Commission in Brussels. As a result of his illustrious career, Dr. Witte has a thorough knowledge of the public funding in Germany and has been successful in raising over $200 million for a number of biotech companies.
“Dr. Witte’s 20 years of financial experience and his specialized expertise in investing in new biotechnologies will make an excellent addition to our Scientific Advisory Board,” said Konstantinos Kardiasmenos, CEO of NextGen. “Dr. Witte’s contributions will form a strategic link to the financial and private equity industries for NextGen.”
David Cooper is Chairman of NextGen’s Board of Directors. For over 30 years David has led David Cooper Associates as an independent business development practice, helping clients achieve commercial advantage from technology based new business development programmes. He has advised clients in identifying opportunities to add value, optimize the allocation of resources, and how to drive the implementation process. DCA sits upon a deep experience of providing flexible strategies based upon well researched advice and creative problem solving in the high risk activity and complexity, and volatile economic climate of the technology based global business market.
Konstantinos Kardiasmenos, NextGen’s CEO holds a Bachelor (with Honors) Degree in Economics from the University of Essex, England and a DEUG (Higher Diploma) in Economics from University of Sorbonne, Paris. He has passed the English FSA Exam for Futures and Options Representative. At Titan Capital Management Ltd. (a fund management company in London) he held the position of Investment Manager and specialized in structured finance until 2001. Konstantinos engineered financial products, which included mutual funds for the Greek market and risk management models. Konstantinos was responsible for raising a total of $7 million in equity for Kotsovolos (largest electric retailer in Greece) and a cosmetics company in London. At PMG SA (Athens based venture capital company) he was Risk Manager until 2004, advising the board of investment opportunities, which brought incremental profits of $5 million over two years. He currently has his own independent financial advisory firm, which advises the biotech, shipping, construction and retail industries.
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