Biological samples comprised of difficult to solubilize structural elements can only be solibulized with fully dissolved analytes, destroying the homogeneity of the samples. These processes are also difficult and time consuming. A new approach however has been developed by Pressure Biosciences Inc. that utilizes alternating levels of Hydrostatic pressure resulting in better preserved Bio samples.
The process they have developed is a considerable advancement over other methods of sample preparation. Barocycler NEP3229 was developed to generate alternating levels of hydrostatic pressure. It allows up to 3 samples to be processed simultaneously in minutes. Extraction parameters can be optimized to the specific sample types and can be conducted in a variety of organic solvents.
Some common challenges of sample preparation include: Rigid cell walls, High Protein and Lipid counts, Mineralization, Digestive enzymes, and complex matrices. All of these can effectively be prepared by the company’s device.
In order for Molecular analysis to be done, the samples must be carefully prepared. The system created by Pressure Biosciences is a great advancement in the initial sample preparation for genomics, proteomics, and purification of biomolecules from cells and tissues. The technology also offers many advantages including: safety, reproducibility, convenience, and above all precise control over the process. New capabilities and potential sample preparation prospects created by the technology give way to new innovative opportunities in drug discovery, diagnostics, and biotechnology.
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